Follistatin-344 Peptide – Myostatin & Activin A Inhibitor
Follistatin-344 (FST-344) is the full-sized, naturally occurring variant of the Follistatin protein, comprising 315 amino acids in its mature form. In the scientific community, it is recognized as a high-affinity binding protein that counteracts the inhibitory signals of Myostatin (GDF8), thereby unlocking the potential for significant muscle cell proliferation.
Key Research Areas:
- Muscle Growth & Hyperplasia: Unlike many other growth-related peptides, Follistatin-344 is studied for its ability to induce both hypertrophy (increased cell size) and hyperplasia (increased number of muscle fibers). Research indicates it may increase muscle mass even in the absence of other growth factors.
- Activin A & Myostatin Inhibition: By binding to Activin A and Myostatin, FST-344 prevents these proteins from attaching to the ActRIIB receptor. This dual action may reduce catabolic pathways that lead to muscle degradation and stiffness.
- Metabolic & Diabetes Research: In murine models, overexpression of Follistatin-344 has been linked to increased pancreatic beta-cell mass. This suggests a potential role in enhancing insulin production and improving glucose regulation in Type 2 Diabetes models.
- Oncology & Metastasis: Research in breast cancer and esophageal carcinoma models suggests that Follistatin levels correlate with prognosis. Studies have explored its ability to prevent the migration of epithelial cells (metastasis) by countering Bone Morphogenic Protein (BMP) activity.
- Anti-Fibrotic Potential: Preliminary studies in liver and muscle tissue suggest FST-344 may reduce fibrosis by up to 32%, potentially improving the lifespan of hepatocytes and the quality of muscle tissue.
Elite Peptide Supply provides premium-grade Follistatin-344 for laboratory use. Our product is synthesized to match the endogenous FST-344 transcript, ensuring high stability and biological relevance for your experiments.
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