PE-22-28 Peptide – The Potent TREK-1 Antagonist for Neuro Research
PE-22-28 is an optimized, truncated version of the naturally occurring peptide Spadin. By narrowing the sequence to the core seven amino acids (GVSWGLR), researchers have developed a compound that exhibits significantly higher stability and receptor affinity than its parent molecule. It serves as a primary tool for probing the TREK-1 (TWIK-related potassium channel-1), a specific two-pore domain potassium channel concentrated in the hippocampus.
Key Research Areas:
- TREK-1 Antagonism: PE-22-28 acts as a potent inhibitor of the TREK-1 channel. In neuroscience, the blockade of this channel is a high-interest area, as genetic deletion of TREK-1 in murine models has been observed to induce resistance to depressive-like behaviors and restore chemical balance.
- Fast-Acting Neurogenic Potential: Unlike traditional research compounds that take weeks to influence signaling, Spadin analogs like PE-22-28 are studied for their potential to induce rapid antidepressant-like effects. Research focuses on its ability to enhance serotonergic neurotransmission and trigger the release of brain-derived neurotrophic factor (BDNF).
- Hippocampal Neurogenesis: Studies investigate the role of PE-22-28 in promoting the birth of new neurons (neurogenesis) in the subdentate gyrus of the hippocampus. This makes it a cornerstone for research into cognitive recovery and the reversal of stress-induced neuronal atrophy.
- Enhanced Molecular Stability: The shortened sequence of PE-22-28 is specifically designed to resist rapid enzymatic degradation. This improved pharmacokinetic profile allows for more consistent results in both in-vitro assays and animal research models.
- Sortilin-Derived Signaling: As a derivative of the sortilin pro-peptide, PE-22-28 allows researchers to map the complex pathways of sortilin-mediated protein trafficking and its impact on mental health and neurological resilience.
Elite Peptide Supply provides high-purity PE-22-28 synthesized for precision neuroscientific inquiry. Our peptide is verified for sequence accuracy to ensure the specific GVSWGLR motif remains active for high-affinity TREK-1 channel targeting.
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