CJC-1295 DAC Peptide – The Long-Acting GHRH Analog for Sustained Research
CJC-1295 DAC is a tetrasubstituted 29-amino acid peptide that mimics the functional action of Growth Hormone-Releasing Hormone. While structurally based on Mod GRF (1-29), the addition of the Drug Affinity Complex fundamentally alters its pharmacokinetics, shifting the research model from pulsatile secretion to a sustained hormonal release profile.
Key Research Areas:
- Extended Pharmacokinetics (DAC): The defining feature of this peptide is the DAC component (N-epsilon-3-maleimidopropionamide) attached via a lysine linker. This allows the peptide to covalently bond to plasma albumin, protecting it from rapid renal filtration and enzymatic degradation, resulting in a half-life of roughly 8 days.
- Tetrasubstituted Stability: Like its “No DAC” counterpart, it features four strategic amino acid substitutions (positions 2, 8, 15, and 27). These modifications, such as the use of D-Alanine, specifically resist breakdown by the DPP-4 enzyme, ensuring the molecule remains bioactive while in circulation.
- Sustained GH & IGF-1 Elevation: Research indicates that CJC-1295 DAC can maintain elevated plasma levels of Growth Hormone and Insulin-like Growth Factor 1 (IGF-1) for extended periods. This makes it an ideal subject for studies investigating the long-term effects of constant somatotroph stimulation.
- Metabolic & Anabolic Signaling: Studies focus on how a constant “bleed” of growth hormone influences fat metabolism, protein synthesis, and cellular repair compared to natural pulsatile rhythms.
- Comparison Studies: Researchers frequently utilize CJC-1295 DAC alongside Mod GRF (1-29) to compare the biological outcomes of continuous versus pulsatile GHRH receptor activation.
Elite Peptide Supply provides high-purity CJC-1295 DAC for professional laboratory use. Our peptide is synthesized to ensure precise DAC conjugation, providing the stability required for longitudinal endocrine research.
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