Pentapeptide-18 (Leuphasyl) Peptide | Leu-Enkephalin Analog | Elite Peptide Supply
Pentapeptide-18, commercially known as Leuphasyl, is a synthetic, modified analog of the endogenous pentapeptide Leu-enkephalin. By substituting glycine with D-Alanine at the second position of its sequence, this peptide achieves enhanced stability and a specific affinity for pathways traditionally associated with opioid receptor interaction.
In dermatological and neurological research, Pentapeptide-18 is studied for its unique mechanism of “expression-line” reduction. Unlike toxins that paralyze muscles, Leuphasyl is hypothesized to work upstream by modulating the electrical charge of the neuron.
Key Research Areas for Pentapeptide-18:
- Synaptic Calcium Modulation: Studies focus on the peptide’s ability to inhibit calcium ion influx across the neuronal synapse, which is a critical trigger for neurotransmitter release.
- Muscle Relaxation: Research explores how interfering with muscle contraction signals can lead to a reduction in the depth of fine lines and wrinkles.
- Epidermal Permeability: Investigated for its ability to penetrate the skin barrier to influence cellular processes at the neuromuscular level.
- Melanogenesis Interaction: Modified versions of this peptide are being examined for their influence on melanin production pathways and their potential protective role against UV-induced tissue damage.
- Enkephalin Mimicry: Used as a model to study the physiological effects of stabilizing naturally occurring enkephalins for prolonged biological action.
Product Specifications:
- Amino Acid Sequence: Tyr-D-Ala-Gly-Phe-Leu
- Molecular Formula: C29H39N5O7
- Molecular Weight: 569.65 g/mol
- Synonyms: Leuphasyl, NSC-374895, Pentapeptide-18
- Purity: ≥99% (HPLC Verified)
- Format: Lyophilized powder for structural integrity.
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