AICAR Peptide – Advanced AMPK Activator for Metabolic Research
AICAR is a synthetic ligand that functions as an analog of adenosine monophosphate (AMP). It is a key tool in metabolic research due to its unique ability to penetrate cell membranes and stimulate AMP-activated protein kinase (AMPK). Often referred to in literature as an “exercise mimetic,” AICAR allows researchers to study energy-deficit states—like hypoxia or hypoglycemia—without actual nutrient deprivation.
Key Research Areas:
- AMPK Pathway Regulation: AICAR is used to study the master metabolic switch, AMPK. Activation of this enzyme in the liver, brain, and skeletal muscles is associated with inhibited cholesterol synthesis, reduced ketogenesis, and increased fatty acid oxidation.
- Cardiovascular Protection: Research on rabbit models suggests AICAR may suppress vascular smooth muscle proliferation and inflammation, potentially reducing complications in atherosclerosis. In ischemic heart models, it has been observed to reduce infarct size by up to 25% and improve overall blood flow.
- Myocardial Glycogenolysis: Studies on isolated working hearts indicate that AICAR increases glycogen degradation (glycogenolysis) through the accumulation of ZMP (the active intracellular form of AICAR). This suggests a potential allosteric activation of glycogen phosphorylase in cardiac tissue.
- Immune Response Modulation: AICAR is being investigated for its role in suppressing macrophage proliferation in response to high LDL levels, a critical step in preventing the inflammatory cascades that lead to heart attacks.
- Metabolic Syndrome & Glucose Uptake: By modulating insulin secretion and enhancing skeletal muscle glucose uptake, AICAR is a primary subject for studies involving Type 2 Diabetes and metabolic dysfunction.
Elite Peptide Supply provides high-purity AICAR for specialized laboratory experimentation. Our compound is synthesized to ensure maximum conversion to ZMP, providing researchers with a reliable model for studying cellular energy balance and cardioprotective mechanisms.
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