FOXO4-DRI Peptide for Research | Senolytic p53 Inhibitor | Elite Peptide Supply
FOXO4-DRI (D-Retro-Inverso) is a modified synthetic analog of the endogenous Forkhead box protein O4. By utilizing D-amino acids in a reversed sequence, this peptide is specifically engineered for superior metabolic stability, a longer half-life, and lower clearance rates compared to its L-amino acid counterparts.
The primary focus of FOXO4-DRI research is its role as a senolytic—a compound that selectively induces apoptosis (programmed cell death) in senescent cells. These “zombie cells” often resist death by binding the FOXO4 protein to p53, effectively inactivating the body’s natural cell-clearing mechanisms.
Key Research Mechanisms & Interests:
- FOXO4-p53 Disruption: Research suggests FOXO4-DRI competes for the binding site of p53. By blocking this interaction, p53 is freed to target pro-apoptotic genes, triggering the death of damaged, senescent cells.
- SASP Mitigation: Studies investigate the peptide’s ability to reduce the Senescence-Associated Secretory Phenotype (SASP)—the release of inflammatory molecules that degrade surrounding healthy tissue.
- Tissue Restoration: Investigators observe how reducing the “old cell burden” may lead to improved organ function, increased cellular differentiation, and enhanced tissue repair.
- Metabolic Signaling: FOXO4-DRI is researched for its influence on insulin signaling pathways, cell cycle regulation, and oxidative stress responses.
- Cellular Permeability: This synthetic version is highly permeable, allowing researchers to study intracellular transcription factor regulation in various tissue models (placenta, fat cells, and adrenal glands).
Product Specifications:
- Sequence: D-form (Leu-Thr-Leu-Arg-Lys-Glu-Pro-Ala-Ser-Glu-Ile-Ala-Gln-Ser-Ile-Leu-Glu-Ala-Tyr-Ser-Gln-Asn-Gly-Trp-Ala-Asn-Arg-Arg-Ser-Gly-Gly-Lys-Arg-Pro-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly)
- Molecular Formula: C228H388N86O64
- Molecular Weight: 5358.05 g/mol
- Synonyms: Proxofim, Forkhead box protein O4, AFX1, MLLT7
- Purity: ≥99% (HPLC Verified)
- Format: Lyophilized powder for maximum stability.
Reviews
There are no reviews yet.