Melanotan 1 (MT-1) Peptide – Advanced Photoprotection Research
Melanotan 1 (MT-1), also known as Afamelanotide, is a linear peptide designed to mimic the biological effects of alpha-melanocyte-stimulating hormone. Through specific amino acid substitutions—replacing L-phenylalanine with D-phenylalanine and methionine with norleucine—MT-1 offers superior receptor affinity and a significantly longer half-life than its natural counterpart.
Key Research Areas:
- Photoprotection & UV Defense: MT-1 is a cornerstone in dermatology research. It has been exhaustively studied for its potential to reduce phototoxicity in models of erythropoietic protoporphyria (EPP). By inducing melanin production, it may shield skin cells from DNA damage caused by UV radiation.
- Melanocortin Receptor Signaling: MT-1 acts as a non-selective agonist across several key receptors:
- MC1R: Located in the skin and hair follicles; responsible for pigmentation and UV response.
- MC3R & MC4R: Found in the central nervous system and hypothalamus; investigated for their roles in appetite regulation and metabolic energy balance.
- MC5R: Distributed across various tissues; currently being explored for its role in exocrine gland function.
- Pigmentation & Hair Research: By interacting with dermal and hair follicle cells, MT-1 is used to investigate the mechanisms of skin darkening and hair follicle melanocyte activation.
- Neurological & Behavioral Impact: Research suggests that through MC4R interaction, MT-1 may influence nerve cells associated with arousal and copulatory behavior in experimental models.
Elite Peptide Supply provides high-purity Melanotan 1 for specialized laboratory use. Our MT-1 is synthesized to ensure maximum molecular stability, making it an essential tool for researchers mapping the melanocortin signaling system.
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