Mod GRF (1-29) Peptide – The Stabilized GHRH Analog for Research
Mod GRF (1-29), often researched under the name CJC-1295 without DAC, is a truncated and optimized version of the natural 44-amino acid GHRH molecule. While the first 29 amino acids (Sermorelin) retain full biological activity, they are highly susceptible to rapid enzymatic breakdown. Mod GRF (1-29) was engineered specifically to solve this stability challenge.
Key Research Area & Modifications:
- Tetrasubstituted Stability: Mod GRF (1-29) features four critical amino acid replacements designed to prevent cleavage and extend its research window:
- Position 2 (D-Alanine): Increases resistance to dipeptidyl peptidase IV (DPP-IV) degradation.
- Position 8 (Lysine): Enhances binding affinity to GHRH receptors for more efficient signaling.
- Position 15 (D-Phenylalanine): Further fortifies the peptide against enzymatic breakdown.
- Position 27 (Sarcosine): Mitigates metabolic clearance, significantly extending the biological half-life.
- Pulsatile GH Secretion: Unlike versions with DAC (Drug Affinity Complex) that cause a continuous “bleed” of hormone, Mod GRF (1-29) preserves the natural, pulsatile rhythm of GH release, allowing for more physiological research data.
- Somatotroph Signaling: Researchers use this peptide to investigate the activation of pituitary somatotrophs and the downstream production of IGF-1, which mediates muscle preservation and tissue repair.
- Comparison to Sermorelin: As a more stable analog, Mod GRF (1-29) is the preferred choice for researchers seeking the benefits of Sermorelin but requiring a longer duration of action for consistent cellular assays.
Elite Peptide Supply provides high-purity Mod GRF (1-29). Our peptide is verified for its tetrasubstituted sequence to ensure researchers receive the exact structural modifications required for high-stability endocrine studies.
Reviews
There are no reviews yet.