The Multimodal Neuropeptide for Immunology Research
VIP (Vasoactive Intestinal Peptide) is a multifunctional signaling molecule produced in the brain, gut, and immune cells. It belongs to the glucagon/secretin superfamily and is distinguished by its broad therapeutic research potential, particularly in its ability to downregulate pro-inflammatory cytokines while supporting cellular homeostasis.
Key Research Areas:
- Pulmonary & Respiratory Research: VIP is extensively studied for its role in the lungs. It acts as a potent bronchodilator and anti-inflammatory agent. Research focuses on its potential to mitigate symptoms in models of Pulmonary Hypertension, COPD, and Sarcoidosis by reducing alveolar inflammation.
- Neuro-Immunomodulation: VIP is a cornerstone of neuro-immunology. It has been observed to inhibit the production of pro-inflammatory cytokines (like TNF-α and IL-6) and promote the development of Regulatory T-cells (Tregs), making it a vital tool for studying autoimmune stability.
- Gastrointestinal Integrity: Originally isolated from the gut, VIP is researched for its ability to regulate intestinal motility and secretion. It is a key subject in studies involving Crohn’s Disease and Ulcerative Colitis, where it may help preserve the mucosal barrier.
- Circadian Rhythm Regulation: In the brain’s suprachiasmatic nucleus (SCN), VIP is essential for synchronizing the biological clock. Researchers use this peptide to investigate sleep-wake cycles and the impact of light on hormonal rhythms.
- Cardiovascular Vasodilation: Studies explore VIP’s ability to relax smooth muscle tissue, leading to vasodilation. This makes it a primary subject for researching blood pressure regulation and cardiac output in ischemic models.
Elite Peptide Supply provides high-purity VIP in a 6mg research format. Our peptide is synthesized to ensure the full 28-amino acid sequence integrity required for high-affinity binding to VPAC1 and VPAC2 receptors in complex biological assays.
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